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Learn about small intestinal submucosa. The magic behind the FISH™ Device.
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SIS® - Small Intestinal Submucosa

Origin

Naturally Occuring -
The Similarities Between Human Tissue & SIS®


Extracellular Matrix

Where It Is Used

Clinical References


SIS® in the Media
Extracellular Matrix
SIS® is a naturally occurring form of extracellular matrix or ECM.

ECM is a bioscaffold that surrounds cells in almost all tissues and organ structures. ECM has both structural and functional roles, and while the composition of the ECM varies by tissue, it is generally composed of four major types of molecules:

Structural Proteins

Collagen and Elastin

Adhesion Glycoproteins
Fibronectin and Laminin

Glycosaminoglycans (GAGs)
and Proteoglycans

Hyaluronan, Heparin Sulfate, Heparin and Dermatan Sulfate

Matricellular Proteins Thrombospondins, Osteopontin
and Tenascins

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